This new electrocatalytic process is a selective, facile and efficient way to obtain spiropyran-2,5′-pyrimidines]. In this research, a novel electrocatalytic multicomponent transformation was found: the electrochemical multicomponent assembly of arylaldehydes, N, N′-dimethylbarbituric acid and 4-hydroxy-6-methyl-2 H-pyran-2-one in one pot reaction was carried out in alcohols in an undivided cell in the presence of alkali metal halides with the selective formation of substituted unsymmetrical 1′,3′,6-trimethyl-3-aryl-2′ H,3 H,4 H-spiropyran-2,5′-pyrimidine]-2′,4,4′,6′(1′ H,3′ H)-tetraones in 73–82% yields. Organic electrochemistry offers an excellent alternative to conventional methods of organic synthesis and creates a modern tool for carrying out organic synthesis, including cascade and multicomponent ones. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.Electrochemical synthesis suggested a mild, green and atom-efficient route to interesting and useful molecules, thus avoiding harsh chemical oxidizing and reducing agents used in traditional synthetic methods. ( en Inventor Wayne KREPPNER Siobhan Fogarty Werner Oberegger Paul Jose Pierre Marie Maes Original Assignee Trimel Biopharma Srl Priority date (The priority date is an assumption and is not a legal conclusion. Google Patents Female intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorderĭownload PDF Info Publication number WO2014083432A2 WO2014083432A2 PCT/IB2013/003121 IB2013003121W WO2014083432A2 WO 2014083432 A2 WO2014083432 A2 WO 2014083432A2 IB 2013003121 W IB2013003121 W IB 2013003121W WO 2014083432 A2 WO2014083432 A2 WO 2014083432A2 Authority WO WIPO (PCT) Prior art keywords testosterone gel formulation formulation subject nasal administration Prior art date Application number PCT/IB2013/003121 Other languages French ( fr) Google Patents WO2014083432A2 - Female intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder WO2014083432A2 - Female intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
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